Impaired degradation of inhibitory subunit of NF - B ( I B ) and - catenin as a result of targeted disruption of the - TrCP 1 gene

Departments of *Molecular Genetics and ‡Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; †Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan; §First Department of Biochemistry, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-0037, Japan; ¶Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan; and Department of Pediatrics, University of South Florida All Children’s Hospital, 801 6th Street South, St. Petersburg, FL 33701-4899